Which statement indicates a client needs additional teaching about statin therapy?

The statement that indicates a client needs additional teaching about statin therapy is the one regarding taking the drug with grapefruit juice. Statins are known to be metabolized by the liver enzyme CYP3A4, and grapefruit juice can inhibit this enzyme, leading to an increased concentration of the statin in the bloodstream. This can heighten the risk of serious side effects, including muscle pain and rhabdomyolysis. Therefore, clients on statin therapy should be instructed to avoid grapefruit juice to prevent potential adverse effects.

In contrast, reporting muscle pain or weakness is essential for clients on statins as these can indicate myopathy, a known side effect of these medications. Taking the dose around bedtime aligns with the pharmacokinetics of statins, which can enhance their efficacy, particularly for certain types of statins that are more effective when taken in the evening. Being careful while out in the sun relates to potential photosensitivity, which may occur with some medications, but it is not a key concern specific to statins.