Which side effect is commonly associated with bile acid sequestrants?

Bile acid sequestrants are a class of lipid-lowering agents that work by binding bile acids in the intestine and preventing their reabsorption. This process promotes the elimination of bile acids through the feces, leading to an increase in the conversion of cholesterol to bile acids in the liver. While they are effective for lowering cholesterol levels, one of the commonly reported side effects of bile acid sequestrants is constipation.

The mechanism behind this side effect is linked to their action in the gastrointestinal tract. By binding bile acids, these agents can alter the normal function of the intestines, leading to reduced bowel motility and consequently constipation. Patients taking bile acid sequestrants often experience gastrointestinal symptoms, and constipation is frequently reported.

Recognizing this common side effect is essential. Physicians often advise patients to maintain adequate hydration and dietary fiber intake to help mitigate the risk of constipation while on these medications. Understanding the side effects associated with bile acid sequestrants helps in managing patient care effectively and ensuring adherence to treatment plans.