Which medication is primarily used to lower triglyceride levels?

Fenofibrate is primarily used to lower triglyceride levels due to its mechanism of action as a fibric acid derivative, or fibrate. Fibrates work by activating peroxisome proliferator-activated receptors (PPARs), particularly PPAR-alpha, which leads to increased lipoprotein lipase activity. This enzyme enhances the breakdown of triglyceride-rich lipoproteins, thereby reducing triglyceride levels in the bloodstream.

In contrast, other medications on the list, such as statins (simvastatin and atorvastatin), primarily focus on lowering low-density lipoprotein (LDL) cholesterol. While they can have a modest effect on triglycerides, their main indication is for managing cholesterol levels rather than triglycerides specifically. Ezetimibe also does not primarily target triglycerides; instead, it works by inhibiting cholesterol absorption in the intestines.

Therefore, given its specific mechanism and primary indication, fenofibrate is the medication most suited for lowering triglyceride levels effectively.