Which lipid-lowering agent is known for raising HDL cholesterol levels?

Niacin, also known as vitamin B3, is distinguished as a lipid-lowering agent specifically noted for its ability to raise high-density lipoprotein (HDL) cholesterol levels. It works by inhibiting the breakdown of fats in adipose tissue, which leads to decreased free fatty acid levels in the liver. Because of this action, the liver produces more HDL cholesterol, thereby increasing its levels in the bloodstream.

Moreover, niacin has multiple beneficial effects on lipid profiles; it can also lower triglycerides and low-density lipoprotein (LDL) cholesterol to some extent. However, its unique capability to significantly elevate HDL cholesterol sets it apart from other lipid-lowering agents. This makes niacin particularly valuable in the context of managing cardiovascular risk, as higher levels of HDL cholesterol are generally associated with a lower risk of heart disease.

The other agents mentioned have different primary effects on lipid levels but do not have the same strong and consistent impact on raising HDL cholesterol as niacin.