Which instruction is most appropriate for a client taking colestipol and a thiazide diuretic?

The most appropriate instruction for a client taking colestipol and a thiazide diuretic is to take the thiazide diuretic about 1 hour before the colestipol. Colestipol is a bile acid sequestrant used to lower cholesterol levels, and it can interfere with the absorption of other medications if taken simultaneously. Therefore, spacing out the administration allows for optimal absorption of both the thiazide diuretic and colestipol.

Taking the thiazide diuretic an hour prior ensures that the medication is absorbed effectively before the colestipol is ingested. This timing helps to minimize any potential interaction that might occur, thereby maximizing the therapeutic effects of both medications.

Understanding the pharmacokinetic interactions between colestipol and thiazide diuretics reinforces the importance of timing in medication administration for individuals who are taking multiple treatments concurrently.