When administering cholestyramine and ezetimibe, when should ezetimibe be taken?

Ezetimibe should be taken four hours after cholestyramine to ensure optimal absorption and effectiveness of both medications. Cholestyramine is a bile acid sequestrant that binds bile acids in the gastrointestinal tract, which can also reduce the absorption of other medications taken at the same time. By spacing the two medications apart, particularly with a four-hour interval, ezetimibe can be adequately absorbed and exert its intended effect of reducing cholesterol absorption in the intestines. This timing prevents cholestyramine from interfering with the absorption of ezetimibe, maximizing the efficacy of lipid-lowering therapy. Ensuring proper timing is crucial in pharmacotherapy to provide the best clinical outcomes for patients managing elevated cholesterol levels.