What lipid level is specifically targeted for reduction with fibrates?

Fibrates are specifically designed to target and reduce high triglyceride levels. They work by activating peroxisome proliferator-activated receptors (PPARs), which enhance the metabolism of fatty acids and decrease the production of triglycerides in the liver. By increasing the breakdown of triglyceride-rich lipoproteins, fibrates effectively lead to lower triglyceride levels in the bloodstream.

While low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels, and total cholesterol are important lipid levels to consider in managing cardiovascular risk, fibrates are particularly notable for their ability to combat hypertriglyceridemia. Therefore, this specific targeting of high triglyceride levels is a key aspect of fibrate therapy in lipid management.