What is the primary role of fibrates in lipid management?

The primary role of fibrates in lipid management is to primarily lower triglyceride levels. Fibrates, such as fenofibrate and gemfibrozil, are specifically effective in decreasing triglyceride concentrations in the blood. They work by activating peroxisome proliferator-activated receptors (PPARs), which enhance the catabolism of triglyceride-rich lipoproteins. This leads to a reduction in triglyceride-rich particles, which is especially beneficial for patients with hypertriglyceridemia or metabolic syndrome.

While fibrates can have a modest effect on increasing HDL (good cholesterol) levels, their most significant clinical benefit is seen in lowering triglycerides. They may also lead to a slight reduction in LDL (bad cholesterol) levels; however, this is not their primary function. Although they have some impact on reducing cardiovascular risk, this is more of a secondary benefit rather than their main role in lipid management. Therefore, the primary focus of fibrates is their ability to effectively lower triglyceride levels, which is why this option is the correct answer.