What is the primary action of fibrates in lipid management?

The primary action of fibrates in lipid management is multifaceted, focusing primarily on both increasing high-density lipoprotein (HDL) cholesterol and decreasing triglycerides. Fibrates are a class of medications that activate peroxisome proliferator-activated receptors (PPARs), which enhance lipid metabolism, leading to significant reductions in triglyceride levels. By doing so, they promote the hydrolysis of triglyceride-rich lipoproteins, thus reducing their levels in the bloodstream.

Additionally, fibrates contribute to an increase in HDL cholesterol levels. HDL is known as "good" cholesterol because it helps transport cholesterol away from the arteries and back to the liver for excretion or recycling. The elevation of HDL levels can have a protective effect against cardiovascular diseases, making the dual action of fibrates beneficial in managing dyslipidemia.

In summary, the correct answer reflects the dual action of fibrates, as they are particularly effective at both lowering triglyceride levels and increasing HDL cholesterol, which is crucial in optimizing lipid profiles and reducing cardiovascular risk.