What is the main purpose of using fibrates in lipid management?

The main purpose of using fibrates in lipid management is to lower triglycerides. Fibrates, such as fenofibrate and gemfibrozil, are primarily indicated for the treatment of hypertriglyceridemia. They work by activating peroxisome proliferator-activated receptors (PPARs), which play a significant role in the regulation of lipid metabolism. This activation leads to increased lipoprotein lipase activity and enhanced fatty acid oxidation, resulting in a reduction in triglyceride levels.

While fibrates do have some positive effects on HDL cholesterol levels, their primary clinical application is not focused on raising HDL. The primary role of fibrates in managing lipid profiles primarily emphasizes their efficacy in lowering elevated triglyceride concentrations. They do not play a significant role in lowering LDL cholesterol or preventing cholesterol absorption, which are better targeted by other medications, such as statins and cholesterol absorption inhibitors. Thus, the correct answer highlights the specific and primary therapeutic goal of fibrates: reducing triglyceride levels.