What is one potential complication of high-dose statin therapy?

Rhabdomyolysis is a serious and potentially life-threatening complication associated with high-dose statin therapy. Statins work by inhibiting the enzyme HMG-CoA reductase, which plays a pivotal role in cholesterol synthesis in the liver. While they are effective in lowering LDL cholesterol and reducing cardiovascular risk, high doses can lead to muscle damage.

Rhabdomyolysis occurs when damaged muscle fibers break down and release myoglobin into the bloodstream. This can lead to kidney damage and other severe complications if not addressed promptly. Symptoms of rhabdomyolysis include muscle pain, weakness, fatigue, and dark urine. Patients on high-dose statins should be monitored for signs of muscle injury, and clinicians may consider monitoring creatine kinase levels, especially if the patient complains of muscle pain or weakness.

In contrast, other listed options such as fluid retention, gastroesophageal reflux, or hypoglycemia are not typically associated with high-dose statin therapy. While some patients may experience muscle cramps or mild gastrointestinal disturbances with statin use, these are not as severe or critical as the risk of rhabdomyolysis. Understanding the potential for this complication is essential for the safe use of statins in managing dyslipidemia.