What is a possible adverse reaction associated with cholestyramine?

Cholestyramine is a bile acid sequestrant used to lower cholesterol levels. One of the well-documented adverse reactions associated with cholestyramine is constipation. This occurs because cholestyramine works by binding bile acids in the intestine, which can lead to decreased bile acid recycling and slowed gastrointestinal motility. The binding process may reduce the bulk and fluid content within the intestines, leading to harder stools and difficulty passing them.

Additionally, cholestyramine can interfere with the absorption of other nutrients and medications due to its mechanism of action. This comprehensive impact on the gastrointestinal system is why constipation is particularly noted among its side effects. While dizziness, memory problems, and abdominal cramping can occur with various medications, they are less commonly associated with cholestyramine than constipation is. Understanding these side effects is essential for managing patient care effectively when using this medication.