In which order should cholestyramine (Questran) be administered relative to other medications?

Cholestyramine (Questran) is a bile acid sequestrant used to lower cholesterol levels. When administering cholestyramine, it is essential to allow adequate time for other medications to be absorbed. Taking cholestyramine too close to other medications can interfere with their absorption, reducing their effectiveness.

Administering cholestyramine one hour after other medications is the correct approach because it ensures that the bile acid sequestrant does not bind to or interfere with the absorption of those drugs. By waiting an hour, the other medications have had sufficient time to enter the bloodstream, thus maximizing their therapeutic effects while minimizing potential interactions. This guideline is crucial in clinical practice to ensure optimal treatment outcomes for patients receiving multiple medications.