In what population are bile acid sequestrants contraindicated?

Bile acid sequestrants are contraindicated in patients with a history of bowel obstruction because these agents work by binding bile acids in the intestine, which can lead to the formation of bulkier intestinal contents. In cases where a patient has a history of bowel obstruction, introducing a bulk-forming agent could exacerbate the condition, potentially resulting in serious complications such as perforation or severe constipation.

These medications can also cause gastrointestinal side effects, such as bloating and constipation, which would be particularly harmful in individuals with a compromised bowel. Therefore, their use in this population is clearly contraindicated to avoid worsening the bowel's physical obstruction and to maintain gastrointestinal health.

Other groups, such as those with heart disease, diabetes, or liver disease, may have specific considerations or adjusted treatment plans, but the contraindication for bile acid sequestrants specifically pertains to the risk of complications from a history of bowel obstruction.