How are high levels of LDL cholesterol related to cardiovascular disease?

High levels of LDL cholesterol, often referred to as "bad" cholesterol, are associated with an increased risk of cardiovascular disease. This is primarily due to the role that LDL plays in the development of atherosclerosis, a condition characterized by the buildup of fatty deposits (plaque) in the arterial walls.

When LDL cholesterol levels are elevated, it can lead to an accumulation of cholesterol in the arteries, which contributes to the formation of plaques. These plaques can narrow the arteries and limit blood flow, increasing the likelihood of cardiovascular events such as heart attacks and strokes. Additionally, the inflammatory response triggered by these plaques can destabilize them, leading to rupture and further cardiovascular complications.

Research consistently shows a strong correlation between elevated LDL cholesterol levels and the incidence of cardiovascular diseases, making it a key target for lipid-lowering therapies aimed at reducing cardiovascular risk.